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Synthesis and sintering of zirconia based ceramics for biomedical applications
Jahodová, Daniela ; Novotná, Lenka (referee) ; Částková, Klára (advisor)
The present thesis focuses on the preparation of tetragonal zirconia doped with yttria oxide, ceric dioxide, and magnesium oxide. In its theoretical part the thesis covers the characteristics of doped ceramics, the possible methods of powders preparation and of their further processing. The experimental part describes the precipitation synthesis of zirconia in base environment and further processing for ceramics. Also studied were the influences of dopant and of the processing technique used on the phase composition and microstructure of the resulting ceramics. To describe the powder structure, the thermal, dilatometric, surface area, and x-ray analyses were performed; as well as both the scanning and transmission electron microscopy employed. Dry processed ceramics showed the average grain size of 87–94 nm and the relative density in the range of 84,0–99,3 %. In comparison, the ceramics produced of hydrothermally synthesised powders proved the average grain size of 75–85 nm and the relative density between 92,7-99,9 %. As the next step, samples were subjected to low-temperature degradation for the time of 5 and 15 hours. Samples consisting of pure tetragonal ZrO2 were resistant to 5 and 15 hours of low-temperature degradation at 180 °C.
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Preparation of nanocrystalline ceramic materials made from zirconia oxide
Vlček, Ondřej ; Prajzler, Vladimír (referee) ; Šťastný, Přemysl (advisor)
Bachelor thesis is focused on preparation of nanocrystalline stabilized zirconia ceramics. The theoretical part is dedicated to zirconia ceramics. Theoretical part describes and unveil the transformation-induced toughening mechanism in partially stabilized zirconia ceramics, the processing routes of these ceramic materials and their utilization. The research part describes preparation of yttria partially stabilized nanocrystalline zirconia ceramics by slip casting method.
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Electrospinning of ceramic fibers
Nemčovský, Jakub ; Kaštyl, Jaroslav (referee) ; Částková, Klára (advisor)
This diploma thesis focuses on the fabrication of ceramic fibres by electrospinning. The theoretical part of the thesis summarizes the currently available information regarding ceramic fibres, their properties, applications and fabrication. The theoretical part also describes the process of electrospinning as one of the most frequently used methods of nanofibre fabrication, as well as the parametres influencing this process. The experimental part is aimed at the fabrication of ceramic fibres based on titania, pure non-doped zirconia and yttria-doped zirconia by electrospinning and at the characterization of thus fabricated fibres. Ceramic precursors based on propoxide and polyvinylpyrrolidone were subjected to electrospinning. The experimental part of this diploma thesis also describes the influence of precursor composition, process conditions and calcination temperature on the morphology and phase composition of the fibres. Precursors were characterized by viscosity measurements. Thermogravimetric analysis (TGA), Röntgen analysis (RTG) and scanning electron microscopy (SEM) were used to describe the fibres. By performing electrospinning of precursors based on titanium propoxide and subsequent calcination at 500-1300 °C, TiO2 fibres with thickness of 100-2500 nm were fabricated. The phase composition changed with calcination temperature from 500 °C from anatase phase through rutile blend to pure rutile at 900 °C. By performing electrospinning of precursors based on zirconium propoxide and subsequent calcination at 550-1100 °C, 0 – 8 mol% Y2O3 doped ZrO2 fibres with thickness of 50-1000 nm were fabricated. An analysis of fibres based on non-doped ZrO2, calcined at 550 °C showed a composition of predominantly monoclinic phase. An analysis of 3 or 8 mol% Y2O3 doped ZrO2 fibres calcined at 900 °C showed a composition of predominantly tetragonal phase or purely cubic phase, respectively. With the increasing calcination temperature, the morphology of the fibres changed from porous nanostructure to chain-like non-porous structure consisting of micrometer grains of TiO2 or ZrO2. The ZrO2 fibres calcined at 700 °C remained flexible as well as the spun ones, while their fragility increased with the increase in calcination temperature.
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Flexible ceramic sheets based on ziconium dioxide
Hliničan, Jan ; Částková, Klára (referee) ; Šťastný, Přemysl (advisor)
The diploma thesis is focused on preparation of thin and highly flexible ceramic tapes from zirconia with a thickness from 70 to 200 m. The thesis is divided into two parts. The first part presents a literary research that focuses on the properties of zirconium dioxide, the preparation of thin ceramic foils and the evaluation of the mechanical properties of ceramic materials. The second part is experimental. It deals with the preparation of thin ceramic foils from colloidal ceramic suspensions produced by epoxy gel-tape casting method. The suspensions were prepared from zirconium dioxide stabilized by 2 and 3 mol.% of yttrium oxide. The maximum deflection and strength was determined on sintered foils. The maximum biaxial strength of 1806 MPa was achieved for 3Y-PC 75 foils with a thickness of 190 m. The maximum deflection of 10.5 mm at a ceramic foil thickness of 75 m was achieved in a 3-point bend with a support span of 30 mm on 3Y-PC 75 samples. At a support distance of 50 mm, the samples were pushed through the gap without damage. These results indicate excellent mechanical properties of the prepared ceramic foils.
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Bioceramic Materials and Their Biocopatibility with Bone Tissues
Novotná, Lenka ; Trunec, Martin (referee) ; Cihlář, Jaroslav (advisor)
The thesis concerns the study of ceramic coatings of zirconia nanoparticles deposited on alumina, zirconia and glass substrates by ultrasonic spraying. The quality of deposits was investigated in dependence on the type of substrate (composition, temperature, roughness) and concentration of ceramic suspension. The best results were received by the deposition of suspension of low concentration on rough substrates at low temperatures. The biocompatibility was tested in vitro. Good cytocompatibility of ceramics with nanostructure coatings was found.
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Neural bioceramic scaffold prepared by freeze-casting
Vojníková, Michaela ; Pejchalová, Lucie (referee) ; Salamon, David (advisor)
Pre regeneráciu a rast poranených nervových vlákien bolo preskúmaných mnoho postupov, no výsledný rast axónov je často náhodný až dezorganizovaný a odráža sa na zložitejšom zotavovaní pacienta. V tejto práci boli vyrobené nové skafoldy s mikroštruktúrnymi a mechanickými vlastnosťami nervového skafoldu pomocou metódy freeze-casting. Konkrétne boli vyrobené biokeramické skafoldy na báze fosforečnanov vápenatých, oxidu titaničitého alebo oxidu zirkoničitého. Pomocou kontrolovaného rastu ľadu v jednom smere bola pripravená orientovaná mikroštruktúra. Pozorovanie pomocou skenovacej elektrónovej mikroskopie potvrdilo lineárne orientované póry (lamelárny systém), v ktorých priemerná veľkosť pórov klesala so zvyšujúcou sa rýchlosťou mrazenia. Skafoldy pripravené pomocou mrazenia v tekutom dusíku vykazovali vynikajúce mechanické vlastnosti, kde pevnosť v ohybe bola získaná v rozmedzí 10–17 MPa. Tie isté skafoldy mali vzdialenosť medzilamelamelárnych priestorov 10–30 µm, ktorých parametre sú vhodné pre nervové skafoldy. Biokompatibilita bola vyhodnotená pomocou Schwannových buniek in vitro, kde bola pozorovaná adhézia a rast v lamelárnom smere. Cytotoxické testy odhalili negatívny vplyv vyššej koncentrácie vápnika na prežitie Schwannových buniek. Pripravené skafoldy mali schopnosť tvorby apatitu na povrchu v podobe embryonálnych a nukleačných centier a apatitu samotného. Skafoldy na báze fosforečnanov vápenatých a oxidu titaničitého vykazovali sľubné regeneračné vlastnosti, konkrétne adhéziu a rast prostredníctvom pórovitej štruktúry a taktiež vynikajúce mechanické vlastnosti.
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Study of bioceramic materials for dental applications
Lokvenc, Martin ; Matoušek, Aleš (referee) ; Novotná, Lenka (advisor)
This thesis deals with bioceramics used in dentistry. The biocompatibility, which is the characteristic property of biomaterials, is described in the opening chapter of the thesis. Advantages and disadvantages of advanced ceramics are also discussed. The main attention was paid particularly to the dental bioceramics, which can be divided according to different criteria. The used classification was based on microstructure, which significantly influences behaviour and properties of biomaterials. The ceramic is viewed as a composite material, where the glass matrix is filled with different amount of crystal phase. The thesis also includes the use of the individual types of bioceramics for the manufacture of dental restorations.
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Neural bioceramic scaffold prepared by freeze-casting
Vojníková, Michaela ; Pejchalová, Lucie (referee) ; Salamon, David (advisor)
Pre regeneráciu a rast poranených nervových vlákien bolo preskúmaných mnoho postupov, no výsledný rast axónov je často náhodný až dezorganizovaný a odráža sa na zložitejšom zotavovaní pacienta. V tejto práci boli vyrobené nové skafoldy s mikroštruktúrnymi a mechanickými vlastnosťami nervového skafoldu pomocou metódy freeze-casting. Konkrétne boli vyrobené biokeramické skafoldy na báze fosforečnanov vápenatých, oxidu titaničitého alebo oxidu zirkoničitého. Pomocou kontrolovaného rastu ľadu v jednom smere bola pripravená orientovaná mikroštruktúra. Pozorovanie pomocou skenovacej elektrónovej mikroskopie potvrdilo lineárne orientované póry (lamelárny systém), v ktorých priemerná veľkosť pórov klesala so zvyšujúcou sa rýchlosťou mrazenia. Skafoldy pripravené pomocou mrazenia v tekutom dusíku vykazovali vynikajúce mechanické vlastnosti, kde pevnosť v ohybe bola získaná v rozmedzí 10–17 MPa. Tie isté skafoldy mali vzdialenosť medzilamelamelárnych priestorov 10–30 µm, ktorých parametre sú vhodné pre nervové skafoldy. Biokompatibilita bola vyhodnotená pomocou Schwannových buniek in vitro, kde bola pozorovaná adhézia a rast v lamelárnom smere. Cytotoxické testy odhalili negatívny vplyv vyššej koncentrácie vápnika na prežitie Schwannových buniek. Pripravené skafoldy mali schopnosť tvorby apatitu na povrchu v podobe embryonálnych a nukleačných centier a apatitu samotného. Skafoldy na báze fosforečnanov vápenatých a oxidu titaničitého vykazovali sľubné regeneračné vlastnosti, konkrétne adhéziu a rast prostredníctvom pórovitej štruktúry a taktiež vynikajúce mechanické vlastnosti.
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Flexible ceramic sheets based on ziconium dioxide
Hliničan, Jan ; Částková, Klára (referee) ; Šťastný, Přemysl (advisor)
The diploma thesis is focused on preparation of thin and highly flexible ceramic tapes from zirconia with a thickness from 70 to 200 m. The thesis is divided into two parts. The first part presents a literary research that focuses on the properties of zirconium dioxide, the preparation of thin ceramic foils and the evaluation of the mechanical properties of ceramic materials. The second part is experimental. It deals with the preparation of thin ceramic foils from colloidal ceramic suspensions produced by epoxy gel-tape casting method. The suspensions were prepared from zirconium dioxide stabilized by 2 and 3 mol.% of yttrium oxide. The maximum deflection and strength was determined on sintered foils. The maximum biaxial strength of 1806 MPa was achieved for 3Y-PC 75 foils with a thickness of 190 m. The maximum deflection of 10.5 mm at a ceramic foil thickness of 75 m was achieved in a 3-point bend with a support span of 30 mm on 3Y-PC 75 samples. At a support distance of 50 mm, the samples were pushed through the gap without damage. These results indicate excellent mechanical properties of the prepared ceramic foils.
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Preparation of nanocrystalline ceramic materials made from zirconia oxide
Vlček, Ondřej ; Prajzler, Vladimír (referee) ; Šťastný, Přemysl (advisor)
Bachelor thesis is focused on preparation of nanocrystalline stabilized zirconia ceramics. The theoretical part is dedicated to zirconia ceramics. Theoretical part describes and unveil the transformation-induced toughening mechanism in partially stabilized zirconia ceramics, the processing routes of these ceramic materials and their utilization. The research part describes preparation of yttria partially stabilized nanocrystalline zirconia ceramics by slip casting method.
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